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KMID : 1038120220550010101
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Clinical Endoscopy
2022 Volume.55 No. 1 p.101 ~ p.112
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Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan
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Amankulov Jandos
Kaidarova Dilyara
Zholdybay Zhamilya
Zagurovskaya Marianna
Baltabekov Nurlan
Gabdullina Madina
Ainakulova Akmaral
Toleshbayev Dias
Panina Alexandra
Satbayeva Elvira
Kalieva Zhansaya
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Abstract
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Background/Aims: The aim of our study was to determine the efficacy of computed tomography colonography (CTC) in screening for colorectal cancer (CRC).
Methods: A total of 612 females and 588 males aged 45 to 75 years were enrolled in CTC screening. CTC was performed following standard bowel preparation and colonic insufflation with carbon dioxide. The main outcomes were the detection rate of CRC and advanced adenoma (AA), prevalence of colorectal lesions in relation to socio-demographic and health factors, and overall diagnostic performance of CTC.
Results: Overall, 56.5% of the 1,200 invited subjects underwent CTC screening. The sensitivity for CRC and AA was 0.89 and 0.97, respectively, while the specificity was 0.71 and 0.99, respectively. The prevalence of CRC and AA was 3.0% (18/593) and 7.1% (42/593), respectively, with the highest CRC prevalence in the 66-75 age group (≥12 times; odds ratio [OR], 12.11; 95% confidence interval [CI], 4.45-32.92). CRC and AA prevalence were inversely correlated with Asian descent, physical activity, and negative fecal immunochemical test results (OR=0.43; 95% CI, 0.22-0.83; OR=0.16; 95% CI, 0.04-0.68; OR=0.5; 95% CI, 0.07-3.85, respectively).
Conclusions: Our study revealed high accuracy of CTC in diagnosing colonic neoplasms, good compliance with CTC screening, and high detection rate of CRC.
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KEYWORD
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Cancer screening, Colonoscopy, Colorectal neoplasms, Computed tomography colonography
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